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Reye’s Syndrome | Health Eagle
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Reye’s Syndrome

by Tom Seman MD FAAP November 10th, 2011 | Pediatrician on Call
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I have heard that giving aspirin to children causes Reye’s Syndrome. Is this true?

Reye’s Syndrome is a constellation of symptoms that occurs when a child under the age of 16 years-old takes aspirin containing medications while ill with influenza, influenza-like diseases, and varicella (chicken pox). The association of aspirin and viral illnesses was discovered in the 1970’s. In 1974, there were 400 cases with upwards of 40% mortality. There are 5 severity grades categorizing the syndrome, helping doctors determine what sort of prognosis the child has for recovery. Signs and symptoms include a child with a viral illness with a high fever that appears to be improving. Then, approximately 5-7 days after the illness started, the child develops severe vomiting, delirium, combative behavior, then stupor, which may lead to coma. Liver damage and long term changes also occur. Therefore, in the late 1970’s, aspirin was removed from all children’s medication products and replaced with acetaminophen. In 1980, only 20 cases of Reye’s Syndrome were reported. The treatment for Reye’s Syndrome has dramatically improved, but the best treatment is – not have it. So please use only approved pediatric medication at appropriate doses.

Have a safe and healthy season.

Good Luck,
DRTOM

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