Wellbutrin is a leading anti-depressant drug from GlaxoSmithKline. Wellbutrin differs from many anti-depressants because it does not have the side effect of reducing sexual appetite (although if you are having sex you should regularly have an HIV test). In fact, Wellbutrin patients commonly report an increased libido. Wellbutrin was first approved by the FDA in 1985, and is still commonly used today.